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S in the trench forming bonds with each of the peptide residues [28]. These studies confirmed earlier predictions that ClfB bound its ligands by the ``dock, lock and latch'' mechanism first defined for the Fg binding proteins SdrG and ClfA [34?5]. After the peptide inserts into the ligandbinding trench a C-terminal extension of domain N3 undergoes a conformational change, covers the inserted pepti
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Ntracellular domain of the AT1 receptors which may also mask the epitopes [177]. An additional post-translational modification is proteolytic cleavage of the receptor into smaller fragments following internalization. Cook et al. [178] demonstrated formation of a 54 amino acid carboxy terminal fragment of the rat AT1a receptor that translocated to the nucleus and induced apoptosis in a variety of c
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Rged residues (Figure S1A) [26]. The Nterminal 542 residues comprise the ligand-binding A domain followed by a flexible stalk formed by repeats of the dipeptide serine-aspartate. The A domain is composed of three separately folded subdomains N1, N2 and N3, the last two of which are the minimum required for binding to ligands Fg and K10 [27?29]. The binding site for ClfB in Fg is a single repeat (n
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. Vaccine delivery systems of the adaptive immune response, combining good safety. Vaccine delivery systems of the adaptive immune response, combining good safety and stability with strong immunogenicity. In conclusion, in this review we have described the advancement obtained in the recent past on the topic of antigen delivery systems for new vaccine formulations. Studies aimed to compare i
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Works Protein folding_Response to unfolded proteins Cell adhesion_Platelet-endothelium-leucocyte interactions Protein folding_ER and cytoplasm Development_Blood vessel morphogenesis Cell adhesion_Cell-matrix interactions Signal transduction_ESR1-nuclear pathway Development_Regulation of angiogenesis Proteolysis_Connective tissue degradation Signal transduction_NOTCH signaling 2.9E-08 9.0E-06 3.8E-
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Imilar topology (Additional file 1, Figure S1). See Additional file 2 for the full list of O. dioica CYP proteins and their accessions. O. dioica (Od) sequences are shown in blue.Yadetie et al. BMC Genomics 2012, 13:55 http://www.biomedcentral.com/1471-2164/13/Page 4 ofCYP3-like-2 (CBY21750) and CYP2-like-11 (CBY24358) genes, respectively (Additional files 3 and 4).Lack of detection of AhR signali
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D in the list of genes used for pathway analysis (see Methods).Pathways affected by BaPcancer, small cell lung cancer and nitrogen metabolism (Table 2). Pathways related to cancer reflect the mouse annotations, but some of the genes in the pathways appear to be involved in conserved cellular processes such as DNA damage and oxidative stress responses. MetaCore enrichment analyses showed most enric
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Is remains only an association and has not been proven unambiguously. Herein we identify a novel interaction between S. aureus ClfB and loricrin that is critically required for S. aureus nasal colonisation. S. aureus was shown to adhere to immobilized human and murine loricrin in a ClfB-dependent fashion. The affinity of recombinant ClfB for human and murine loricrin was comparable to K10 and Fg b