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Ks (Additional fileTable 3 Enriched Pathway Maps (A) and Process Networks (B) for genes differentially regulated by BaPRank 1 2 3 4 5 6 7 8 9 10 1 2 3 4 5 6 7 8 9 10 A. Pathway Maps Apoptosis and survival_ER stress response pathway NRF2 regulation of oxidative stress response Role of alpha-6/beta-4 integrins in carcinoma progression Mechanisms of CFTR activation by S-nitrosoglutathione Immune resp
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Ntracellular domain of the AT1 receptors which may also mask the epitopes [177]. An additional post-translational modification is proteolytic cleavage of the receptor into smaller fragments following internalization. Cook et al. [178] demonstrated formation of a 54 amino acid carboxy terminal fragment of the rat AT1a receptor that translocated to the nucleus and induced apoptosis in a variety of c
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Ares of rodents [22?3] and in the case of ClfB, humans [24]. S. aureus surface protein G (SasG) and the serine-aspartate repeat proteins SdrC and SdrD also promote bacterial adhesion to squames in vitro [25] but their roles, if any, in vivo have not yet been tested. ClfB is a member of a family of proteins that are structurally related to clumping factor A (ClfA), the archetypal fibrinogenPLOS Pat
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S in the trench forming bonds with each of the peptide residues [28]. These studies confirmed earlier predictions that ClfB bound its ligands by the ``dock, lock and latch'' mechanism first defined for the Fg binding proteins SdrG and ClfA [34?5]. After the peptide inserts into the ligandbinding trench a C-terminal extension of domain N3 undergoes a conformational change, covers the inserted pepti
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4]. Related to the OI story, the serpins, proteins which regulate protease activities, are IDPs, and serpin F1 mutations are associated with type V OI [153]. Another possible example of defective IDPs leading to bone disease is osteoporosis which has been associated with defects in osteonectin [156], which, as noted above has IDP regions. Osteopontin deficiency results in dystrophic calcification
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Ulum stress response". Mouse homologs of genes differentially regulated by BaP in Oikopleura are indicated on the pathway map by thermometer like symbols (encircled for clarity). See Additional file 5 for detailed figure legend.6). One of the BaP-induced key transcription factors, JunD is a functional component of the AP-1 transcription factor complex. AP-1 is one of the top ranked transcription f
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Is remains only an association and has not been proven unambiguously. Herein we identify a novel interaction between S. aureus ClfB and loricrin that is critically required for S. aureus nasal colonisation. S. aureus was shown to adhere to immobilized human and murine loricrin in a ClfB-dependent fashion. The affinity of recombinant ClfB for human and murine loricrin was comparable to K10 and Fg b
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Is remains only an association and has not been proven unambiguously. Herein we identify a novel interaction between S. aureus ClfB and loricrin that is critically required for S. aureus nasal colonisation. S. aureus was shown to adhere to immobilized human and murine loricrin in a ClfB-dependent fashion. The affinity of recombinant ClfB for human and murine loricrin was comparable to K10 and Fg b